pancreatic polypeptide การใช้

• Most islet cell tumors secrete pancreatic polypeptide, the clinical significance of which is unknown.
• PP-cells produce pancreatic polypeptide which is a regulator of endocrine and exocrine secretions in the pancreas and gut.
• :: Going to Islets of Langerhans is more useful-it tells you PP cells are gamma cells, which secrete pancreatic polypeptide.
• The first line, under the direction of a Pax gene, forms ?-and ?-cells, which produce glucagon and pancreatic polypeptides, respectively.
• The endocrine cells constitute the beta cells which make insulin, alpha cells which secrete glucagon, delta cells which secrete somatostatin and the PP-cells which secrete pancreatic polypeptide.
• One of the more serious side effects is dehydration ( loss of water ) which for certain peptides can be almost quantitative like pancreatic polypeptide ( PP ).
• Additionally endocrine progenitor cells also form Nkx2.2 + PP cell pro-precursors, which then are determined to form PP + ( Pancreatic polypeptide ) precursor cells and later PP-cells.
• Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells.
• The islets are the source of insulin, the hormone that alerts cells to take up glucose from the blood, and they also generate three lesser-known hormones called glucagon, somatostatin and pancreatic polypeptide, each produced by a different type of cell.
• Up to 60 % of PanNETs are nonsecretory or nonfunctional, which either don t secrete, or the quantity or type of products such as pancreatic polypeptide ( PPoma ), chromogranin A, and neurotensin do not cause a clinical syndrome, although blood levels may be elevated.